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Image Search Results
Journal: American Journal of Physiology - Heart and Circulatory Physiology
Article Title: Apoptosis signal-regulating kinase 1 activation by Nox1-derived oxidants is required for TNFα receptor endocytosis
doi: 10.1152/ajpheart.00741.2018
Figure Lengend Snippet: Effects of siASK1 on superoxide production and TNFR endocytosis. A: the CAT1H signal in the media following TNFα exposure was not altered by siASK1, demonstrating that extracellular superoxide production in response to TNFα is not ASK1 dependent (n = 3). B: endocytosis of TNFR in VSMCs was impaired by siASK1. Bar graphs reflect fluorescent dots per cell. *P < 0.05 vs. siControl 0 min. †P < 0.05. C: representative images show that TNFR endocytosis (white dots) is reduced by siASK1. Results are representative of at least three independent experiments. D: TNFα-induced intracellular superoxide production is attenuated by siASK1. Total intracellular superoxide production was quantified using TMH. Representative electron spin resonance spectra for TMH (left) and means ± SE data (right). *P < 0.05 vs. siControl. †P < 0.05 (n = 4). ASK1, apoptosis signal-regulating kinase 1; CAT1H, 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride; TMH, 1-hydroxy-4-methoxy-2,2,6,6-tetramethylpiperidine; TNFR, tumor necrosis factor receptor; VSMC, vascular smooth muscle cell.
Article Snippet: For quantification of superoxide production, the
Techniques: Electron Paramagnetic Resonance
Journal: Frontiers in Neuroscience
Article Title: Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis
doi: 10.3389/fnins.2022.1084362
Figure Lengend Snippet: Studies entered into the meta-analysis are listed based on the year of publication.
Article Snippet: , 6 , Right , Unilateral ,
Techniques: Blocking Assay